IGHV1OR16-4

Across TCGA pan-cancer cohorts, IGHV1OR16-4 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of IGHV1OR16-4’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGHV1OR16-4 RNA is repressed in tumor relative to normal tissue. In most cancer types IGHV1OR16-4 is over-expressed in tumor, although a few such as COAD and STAD show the opposite, repressed pattern.

COAD, LUAD, and KIRC are the cancer types where IGHV1OR16-4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHV1OR16-4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	−0.597	<.001	8	view →
LUAD	All	All	+0.477	<.001	6	view →
KIRC	Male	IV	+0.115	.013	5	view →
STAD	Male	IV	−1.600	.007	2	view →
READ	Female	All	−0.540	.026	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

IGHV1OR16-4–COAD

Open the COAD breakdown →