IGHV1OR15-4

Across TCGA patient cohorts, IGHV1OR15-4 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,390 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible IGHV1OR15-4-associated GO terms across cancer lineages are Antimicrobial humoral response, Immunoglobulin production, and Humoral immune response mediated by circulating immunoglobulin. Each is linked with IGHV1OR15-4 in more than 19 cancer types. Because this analysis shows association rather than direction, both IGHV1OR15-4-to-partner and partner-to-IGHV1OR15-4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Antimicrobial humoral response grouped by IGHV1OR15-4-low versus IGHV1OR15-4-high in THCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV1OR15-4→partner) and Y-score (partner→IGHV1OR15-4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THCA	Antimicrobial humoral response →	+0.121	+0.175	<.001	<.001	3	20
THCA	Immunoglobulin production →	+0.079	+0.194	<.001	<.001	3	19
THCA	Humoral immune response mediated by circulating immunoglobulin →	+0.148	+0.163	<.001	<.001	3	19
SKCM	Positive regulation of leukocyte proliferation →	+0.050	+0.111	<.001	<.001	3	18
THCA	B cell mediated immunity →	+0.110	+0.195	<.001	<.001	3	18
THCA	Antibacterial humoral response →	+0.172	+0.179	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,390 associations by consensus.

Antimicrobial humoral response by IGHV1OR15-4 expression — THCA

Explore this box plot interactively →