IGHV1OR15-4

Across TCGA pan-cancer cohorts, IGHV1OR15-4 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of IGHV1OR15-4’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where IGHV1OR15-4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IGHV1OR15-4 is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.

LUAD, COAD, and HNSC are the cancer types where IGHV1OR15-4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHV1OR15-4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	All	+0.328	<.001	9	view →
COAD	Female	II,III,IV	−0.175	<.001	5	view →
HNSC	All	II,III,IV	+0.078	.033	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

IGHV1OR15-4–LUAD

Open the LUAD breakdown →