IGHV1OR15-4

Across TCGA pan-cancer cohorts, IGHV1OR15-4 RNA is linked to patient survival in 12 of 34 cancer types, making it the most broadly survival-associated IGHV1OR15-4 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV1OR15-4 RNA is associated with better overall survival. In most high-consensus cancer types, elevated IGHV1OR15-4 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, KIRP, and SKCM are the cancer types where IGHV1OR15-4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.778	0.617	<.001	164	view →
KIRP	OS	Tertile	II,III,IV	0.101	0.582	.001	81	view →
SKCM	DFS	Tertile	III,IV	0.819	0.444	.004	42	view →
LUAD	DFS	Quartile	All	0.544	0.320	.008	33	view →
LGG	DFS	Tertile	All	0.432	0.830	.003	27	view →
LUSC	DFS	Median	All	0.802	0.729	.019	18	view →
CHOL	DFS	Tertile	III,IV	1.000	0.182	.034	9	view →
STAD	OS	Tertile	IV	0.642	0.203	.006	9	view →
THCA	OS	Tertile	IV	0.813	1.000	.039	9	view →
BRCA	OS	Tertile	IV	1.000	0.643	.036	6	view →
BLCA	DFS	Tertile	III,IV	0.570	0.418	.043	3	view →
LIHC	DFS	Tertile	All	0.688	0.527	.040	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

IGHV1OR15-4–HNSC (OS)

Open the HNSC breakdown →