IGHV1OR15-3

Across TCGA patient cohorts, IGHV1OR15-3 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,566 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible IGHV1OR15-3-associated GO terms across cancer lineages are B cell mediated immunity, Negative regulation of cell activation, and Antimicrobial humoral response. Each is linked with IGHV1OR15-3 in more than 26 cancer types. Because this analysis shows association rather than direction, both IGHV1OR15-3-to-partner and partner-to-IGHV1OR15-3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, B cell mediated immunity grouped by IGHV1OR15-3-low versus IGHV1OR15-3-high in THCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV1OR15-3→partner) and Y-score (partner→IGHV1OR15-3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THCA	B cell mediated immunity →	+0.105	+0.294	<.001	<.001	3	27
SKCM	Negative regulation of cell activation →	+0.046	+0.232	<.001	<.001	3	24
SARC	Antimicrobial humoral response →	+0.123	+0.282	<.001	.001	3	24
ESCA	Immunoglobulin production →	+0.080	+0.470	<.001	<.001	3	24
THCA	Humoral immune response mediated by circulating immunoglobulin →	+0.147	+0.259	<.001	<.001	3	24
SKCM	Positive regulation of production of molecular mediator of immune response →	+0.032	+0.194	<.001	<.001	3	24

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,566 associations by consensus.

B cell mediated immunity by IGHV1OR15-3 expression — THCA

Explore this box plot interactively →