IGHV1OR15-3

Across TCGA pan-cancer cohorts, IGHV1OR15-3 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated IGHV1OR15-3 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV1OR15-3 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGHV1OR15-3 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BRCA show a favorable association.

HNSC, BRCA, and UVM are the cancer types where IGHV1OR15-3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.808	0.655	<.001	116	view →
BRCA	DFS	Tertile	All	0.982	0.937	<.001	107	view →
UVM	OS	Tertile	All	0.315	0.864	<.001	99	view →
SKCM	OS	Tertile	All	0.477	0.283	<.001	89	view →
KIRP	DFS	Tertile	All	0.435	0.815	<.001	57	view →
LGG	OS	Tertile	All	0.147	0.458	<.001	48	view →
DLBC	DFS	Tertile	II,III,IV	0.065	0.829	<.001	42	view →
THCA	OS	Tertile	III,IV	0.850	0.963	.007	36	view →
CHOL	DFS	Tertile	All	0.856	0.264	.010	30	view →
LUAD	DFS	Quartile	III,IV	0.852	0.345	.004	25	view →
PAAD	DFS	Median	All	0.253	0.419	.007	18	view →
GBM	OS	Tertile	All	0.070	0.416	.003	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

IGHV1OR15-3–HNSC (DFS)

Open the HNSC breakdown →