IGHV1OR15-3

Across TCGA pan-cancer cohorts, IGHV1OR15-3 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of IGHV1OR15-3’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGHV1OR15-3 RNA is repressed in tumor relative to normal tissue. In most cancer types IGHV1OR15-3 is over-expressed in tumor, although a few such as COAD and BRCA show the opposite, repressed pattern.

COAD, LUAD, and KIRC are the cancer types where IGHV1OR15-3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHV1OR15-3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−0.421	<.001	9	view →
LUAD	Female	All	+0.375	<.001	3	view →
KIRC	Male	All	+0.050	.022	3	view →
HNSC	All	IV	+0.138	.039	2	view →
BRCA	All	III,IV	−0.134	.022	2	view →
READ	Female	All	−0.504	.002	1	view →
ESCA	All	All	+0.317	.025	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

IGHV1OR15-3–COAD

Open the COAD breakdown →