IGHV1-69D

Across TCGA patient cohorts, IGHV1-69D protein abundance is significantly associated with the RNA expression of many other genes, with 2,267 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible IGHV1-69D-associated genes across cancer lineages are EFCAB11, MARVELD2, and ZCCHC10. Each is linked with IGHV1-69D in more than 2 cancer types. Because this analysis shows association rather than direction, both IGHV1-69D-to-partner and partner-to-IGHV1-69D results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGHV1-69D versus EFCAB11 in BRCA, with a Pearson correlation of -0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV1-69D→partner) and Y-score (partner→IGHV1-69D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	EFCAB11 →	-0.524	-1.023	.001	<.001	3	2
BRCA	MARVELD2 →	-0.503	-1.002	<.001	<.001	3	2
BRCA	ZCCHC10 →	-0.457	-1.187	.005	<.001	2	3
BRCA	FCHO2 →	-0.563	-0.822	.001	<.001	3	2
BRCA	CYB5A →	-0.809	-1.071	.002	<.001	3	2
BRCA	ZNF680 →	-0.594	-0.835	.004	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,267 associations by consensus.

IGHV1-69D vs EFCAB11 — BRCA

Explore this scatter interactively →