IGHV1-69D

Across TCGA pan-cancer cohorts, IGHV1-69D RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated IGHV1-69D data layer compared with 3 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV1-69D RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGHV1-69D expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and BRCA are the cancer types where IGHV1-69D RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.755	0.634	<.001	143	view →
SKCM	OS	Median	II,III,IV	0.932	0.752	<.001	97	view →
BRCA	DFS	Quartile	All	0.974	0.921	.002	68	view →
KIRP	OS	Tertile	All	0.559	0.777	.003	41	view →
UCEC	OS	Tertile	III,IV	0.729	0.398	.007	36	view →
GBM	OS	Tertile	All	0.277	0.455	<.001	25	view →
OV	DFS	Tertile	II,III,IV	0.430	0.329	.009	22	view →
TGCT	DFS	Quartile	All	0.971	0.787	.011	16	view →
LUAD	OS	Median	II,III,IV	0.703	0.502	.011	13	view →
COAD	DFS	Median	II,III,IV	0.770	0.600	.016	13	view →
LUSC	OS	Median	III,IV	0.517	0.178	<.001	13	view →
SARC	OS	Median	All	0.881	0.794	.015	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

IGHV1-69D–HNSC (DFS)

Open the HNSC breakdown →