IGHV1-69D

Across TCGA pan-cancer cohorts, IGHV1-69D RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of IGHV1-69D’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGHV1-69D RNA is repressed in tumor relative to normal tissue. In most cancer types IGHV1-69D is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

COAD, LUAD, and HNSC are the cancer types where IGHV1-69D tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHV1-69D RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−4.348	<.001	9	view →
LUAD	Male	All	+2.484	<.001	8	view →
HNSC	Female	III,IV	+3.020	.013	4	view →
KIRC	Male	All	+1.565	<.001	4	view →
KICH	Female	All	−2.028	.031	3	view →
READ	Female	All	−3.084	.012	2	view →
LIHC	Male	All	−2.194	<.001	2	view →
LUSC	All	All	+0.948	.035	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

IGHV1-69D–COAD

Open the COAD breakdown →