IGHV1-68

Across TCGA patient cohorts, IGHV1-68 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,771 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible IGHV1-68-associated GO terms across cancer lineages are B cell mediated immunity, Complement activation, classical pathway, and B cell receptor signaling pathway. Each is linked with IGHV1-68 in more than 28 cancer types. Because this analysis shows association rather than direction, both IGHV1-68-to-partner and partner-to-IGHV1-68 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, B cell mediated immunity grouped by IGHV1-68-low versus IGHV1-68-high in THCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV1-68→partner) and Y-score (partner→IGHV1-68) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THCA	B cell mediated immunity →	+0.097	+0.625	<.001	<.001	3	29
THCA	Complement activation, classical pathway →	+0.192	+0.574	<.001	<.001	3	27
SKCM	B cell receptor signaling pathway →	+0.079	+0.482	<.001	<.001	3	26
THCA	Complement activation →	+0.154	+0.566	<.001	<.001	3	26
SARC	Antimicrobial humoral response →	+0.111	+0.197	<.001	<.001	3	26
THCA	Antibacterial humoral response →	+0.170	+0.558	<.001	<.001	3	26

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,771 associations by consensus.

B cell mediated immunity by IGHV1-68 expression — THCA

Explore this box plot interactively →