IGHV1-68

Across TCGA pan-cancer cohorts, IGHV1-68 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of IGHV1-68’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGHV1-68 RNA is repressed in tumor relative to normal tissue. In most cancer types IGHV1-68 is over-expressed in tumor, although a few such as COAD and BRCA show the opposite, repressed pattern.

COAD, LUAD, and BRCA are the cancer types where IGHV1-68 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHV1-68 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−1.220	<.001	7	view →
LUAD	All	All	+0.664	<.001	7	view →
BRCA	Female	II,III,IV	−0.158	.014	4	view →
PAAD	Female	All	−0.415	.007	2	view →
READ	Female	All	−0.862	.048	1	view →
LUSC	All	All	+0.375	.049	1	view →
LIHC	Male	All	−0.101	.025	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

IGHV1-68–COAD

Open the COAD breakdown →