IGHV1-68

Across TCGA pan-cancer cohorts, IGHV1-68 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated IGHV1-68 data layer compared with 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV1-68 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGHV1-68 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and CESC are the cancer types where IGHV1-68 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.769	0.596	<.001	122	view →
SKCM	OS	Median	All	0.489	0.277	<.001	101	view →
CESC	DFS	Quartile	IV	0.722	0.296	.014	46	view →
GBM	OS	Tertile	All	0.030	0.416	<.001	27	view →
LUAD	DFS	Tertile	II,III,IV	0.707	0.472	.012	23	view →
COAD	OS	Tertile	IV	1.000	0.341	.025	18	view →
UCS	DFS	Tertile	II,III,IV	0.181	0.471	.032	18	view →
KIRP	DFS	Tertile	All	0.552	0.809	.037	12	view →
READ	DFS	Tertile	III,IV	0.563	0.212	.011	9	view →
BRCA	DFS	Median	III,IV	0.919	0.834	.029	8	view →
KIRC	DFS	Median	All	0.781	0.900	.018	8	view →
BLCA	OS	Median	IV	0.591	0.284	.036	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

IGHV1-68–HNSC (DFS)

Open the HNSC breakdown →