IGHV1-24

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, IGHV1-24 mutation is significantly associated with the RNA expression of many other genes, with 255 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible IGHV1-24-associated genes across cancer lineages are RNA5SP71, RPSAP37, and MIR217. Each is linked with IGHV1-24 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGHV1-24-to-partner and partner-to-IGHV1-24 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV1-24→partner) and Y-score (partner→IGHV1-24) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LUADRNA5SP71 →+0.596+4.330<.001.00232
SKCMRPSAP37 →+0.019+3.282<.001.00532
LUSCMIR217 →+0.328+4.309<.001.00732
LUSCMIR608 →+0.327+3.739<.001.00532
LUSCRNU6-1057P →+0.396+3.881<.001.00432
SKCMRNU6-1137P →+0.151+3.095<.001.00732
Each partner links to its Q-omics profile. Showing the 6 strongest of 255 associations by consensus.

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