Across TCGA patient cohorts, IGHV1-2 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible IGHV1-2-associated genes across cancer lineages are OR14J1, ANAPC1P3, and TUBB4BP6. Each is linked with IGHV1-2 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGHV1-2-to-partner and partner-to-IGHV1-2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV1-2→partner) and Y-score (partner→IGHV1-2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	OR14J1 →	+0.042	+4.792	<.001	.006	3	1
LUSC	ANAPC1P3 →	+0.185	+4.236	.004	.008	3	1
LUSC	TUBB4BP6 →	+0.116	+5.191	<.001	.003	3	1
LUSC	RN7SL563P →	+0.205	+4.392	.007	.006	3	1
LUSC	BMS1P3 →	+0.045	+4.882	<.001	.005	3	1
LUSC	NDUFS6P1 →	+0.151	+4.625	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Exploration

IGHV1-2 survival (RNA) · tumor vs normal (RNA) · all IGHV1-2 data types