Across TCGA pan-cancer cohorts, IGHV1-2 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of IGHV1-2’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where IGHV1-2 RNA is repressed in tumor relative to normal tissue. In most cancer types IGHV1-2 is over-expressed in tumor, although a few such as COAD and READ show the opposite, repressed pattern.
COAD, LUAD, and READ are the cancer types where IGHV1-2 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHV1-2 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.