Across TCGA patient cohorts, IGHV1-18 protein abundance is significantly associated with the RNA expression of many other genes, with 11,941 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IGHV1-18-associated genes across cancer lineages are SAMSN1, PNOC, and JAK3. Each is linked with IGHV1-18 in more than 6 cancer types. Because this analysis shows association rather than direction, both IGHV1-18-to-partner and partner-to-IGHV1-18 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV1-18→partner) and Y-score (partner→IGHV1-18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SAMSN1 →	+0.972	+0.962	<.001	<.001	3	7
UCEC	PNOC →	+0.841	+0.792	.001	<.001	3	7
UCEC	JAK3 →	+0.916	+0.796	<.001	.001	3	6
LUAD	FCRLA →	+0.824	+0.459	<.001	<.001	3	6
UCEC	P2RY8 →	+0.843	+0.920	<.001	.002	3	6
UCEC	FAM30A →	+1.158	+1.192	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,941 associations by consensus.

Exploration

IGHV1-18 survival (RNA) · tumor vs normal (RNA) · all IGHV1-18 data types