IGHV1-14

Across TCGA patient cohorts, IGHV1-14 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,056 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible IGHV1-14-associated GO terms across cancer lineages are B cell activation, B cell receptor signaling pathway, and Alpha-beta T cell activation. Each is linked with IGHV1-14 in more than 30 cancer types. Because this analysis shows association rather than direction, both IGHV1-14-to-partner and partner-to-IGHV1-14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, B cell activation grouped by IGHV1-14-low versus IGHV1-14-high in CHOL.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV1-14→partner) and Y-score (partner→IGHV1-14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	B cell activation →	+0.063	+1.326	<.001	.001	3	30
CHOL	B cell receptor signaling pathway →	+0.099	+1.178	<.001	.003	3	30
CHOL	Alpha-beta T cell activation →	+0.065	+1.415	<.001	.001	2	30
CHOL	Antigen receptor-mediated signaling pathway →	+0.071	+1.294	<.001	.001	1	31
SKCM	Regulation of leukocyte proliferation →	+0.049	+0.831	<.001	<.001	3	29
THCA	Humoral immune response mediated by circulating immunoglobulin →	+0.161	+1.131	<.001	<.001	3	29

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,056 associations by consensus.

B cell activation by IGHV1-14 expression — CHOL

Explore this box plot interactively →