IGHV1-14

Across TCGA pan-cancer cohorts, IGHV1-14 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of IGHV1-14’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGHV1-14 RNA is repressed in tumor relative to normal tissue. In most cancer types IGHV1-14 is over-expressed in tumor, although a few such as COAD and BRCA show the opposite, repressed pattern.

COAD, LUAD, and BRCA are the cancer types where IGHV1-14 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHV1-14 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−1.524	<.001	9	view →
LUAD	Female	All	+1.545	<.001	7	view →
BRCA	Female	All	−0.384	.001	6	view →
KIRC	All	All	+0.511	<.001	5	view →
STAD	All	IV	−3.456	.040	2	view →
READ	All	All	−1.841	.001	2	view →
KIRP	Female	II,III,IV	−0.300	.044	2	view →
LUSC	All	All	+0.547	.031	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

IGHV1-14–COAD

Open the COAD breakdown →