IGHV1-14

Across TCGA pan-cancer cohorts, IGHV1-14 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated IGHV1-14 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV1-14 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGHV1-14 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BRCA show a favorable association.

HNSC, BRCA, and ACC are the cancer types where IGHV1-14 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.688	0.519	<.001	144	view →
BRCA	DFS	Median	All	0.610	0.457	<.001	69	view →
ACC	DFS	Tertile	III,IV	0.010	0.458	<.001	63	view →
SKCM	OS	Quartile	All	0.465	0.293	.003	62	view →
GBM	OS	Tertile	All	0.223	0.433	<.001	36	view →
UVM	OS	Tertile	III,IV	0.104	0.813	.001	27	view →
DLBC	DFS	Tertile	II,III,IV	0.476	1.000	.003	24	view →
PAAD	OS	Tertile	II,III,IV	0.672	0.476	.012	22	view →
CHOL	DFS	Quartile	All	0.809	0.273	.006	21	view →
READ	DFS	Median	IV	0.760	0.394	.016	20	view →
UCEC	OS	Tertile	III,IV	0.728	0.479	.015	16	view →
TGCT	DFS	Quartile	All	0.976	0.773	.004	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

IGHV1-14–HNSC (DFS)

Open the HNSC breakdown →