IGHV1-12

Across TCGA patient cohorts, IGHV1-12 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,102 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible IGHV1-12-associated GO terms across cancer lineages are B cell receptor signaling pathway, B cell activation, and Mononuclear cell migration. Each is linked with IGHV1-12 in more than 30 cancer types. Because this analysis shows association rather than direction, both IGHV1-12-to-partner and partner-to-IGHV1-12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, B cell receptor signaling pathway grouped by IGHV1-12-low versus IGHV1-12-high in CHOL.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV1-12→partner) and Y-score (partner→IGHV1-12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	B cell receptor signaling pathway →	+0.115	+2.004	<.001	<.001	3	31
CHOL	B cell activation →	+0.063	+2.292	<.001	<.001	3	31
ESCA	Mononuclear cell migration →	+0.057	+1.252	<.001	<.001	3	30
THCA	Complement activation →	+0.156	+2.068	<.001	<.001	3	30
THCA	Complement activation, classical pathway →	+0.201	+2.087	<.001	<.001	3	30
CHOL	Respiratory burst →	+0.092	+1.686	<.001	<.001	3	30

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,102 associations by consensus.

B cell receptor signaling pathway by IGHV1-12 expression — CHOL

Explore this box plot interactively →