Across TCGA patient cohorts, IGHG3 protein abundance is significantly associated with the RNA expression of many other genes, with 9,702 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IGHG3-associated genes across cancer lineages are FCRL5, CR1, and IGHV2-26. Each is linked with IGHG3 in more than 6 cancer types. Because this analysis shows association rather than direction, both IGHG3-to-partner and partner-to-IGHG3 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHG3→partner) and Y-score (partner→IGHG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FCRL5 →	+0.839	+0.587	<.001	<.001	3	7
GBM	CR1 →	+0.934	+0.603	<.001	<.001	3	7
OV	IGHV2-26 →	+2.035	+0.815	.002	<.001	3	7
BRCA	IGHV4-34 →	+2.746	+0.705	<.001	<.001	3	7
OV	IGHV3-30 →	+2.444	+0.795	.004	<.001	3	7
BRCA	CD79A →	+1.450	+0.453	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,702 associations by consensus.

Exploration

IGHG3 survival (RNA) · tumor vs normal (RNA) · all IGHG3 data types