IGHD7-27

Across TCGA patient cohorts, IGHD7-27 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,965 significant associations in total. COAD shows the largest number of these associations.

The most reproducible IGHD7-27-associated GO terms across cancer lineages are Thymic T cell selection, Leukocyte apoptotic process, and Positive T cell selection. Each is linked with IGHD7-27 in more than 15 cancer types. Because this analysis shows association rather than direction, both IGHD7-27-to-partner and partner-to-IGHD7-27 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Thymic T cell selection grouped by IGHD7-27-low versus IGHD7-27-high in LIHC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHD7-27→partner) and Y-score (partner→IGHD7-27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	Thymic T cell selection →	+0.126	+0.197	<.001	.006	3	16
BLCA	Leukocyte apoptotic process →	+0.075	+0.358	<.001	<.001	3	16
CESC	Positive T cell selection →	+0.108	+0.126	<.001	.004	3	15
BLCA	Regulation of B cell activation →	+0.080	+0.158	<.001	<.001	3	15
CESC	Regulation of leukocyte apoptotic process →	+0.076	+0.189	<.001	.004	2	16
BLCA	T cell differentiation in thymus →	+0.069	+0.161	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,965 associations by consensus.

Thymic T cell selection by IGHD7-27 expression — LIHC

Explore this box plot interactively →