IGHD7-27

Across TCGA pan-cancer cohorts, IGHD7-27 RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated IGHD7-27 data layer.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher IGHD7-27 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated IGHD7-27 expression acts as an unfavorable survival marker, although some lineages such as OV and READ show a favorable association.

UCEC, CHOL, and STAD are the cancer types where IGHD7-27 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Tertile	All	0.241	0.719	<.001	108	view →
CHOL	OS	Tertile	All	0.019	0.800	<.001	72	view →
STAD	OS	Tertile	IV	0.052	0.496	.002	60	view →
LUAD	DFS	Tertile	IV	0.320	0.724	.016	18	view →
TGCT	OS	Tertile	All	0.867	0.967	.046	18	view →
LUSC	OS	Tertile	III,IV	0.054	0.768	<.001	18	view →
LAML	DFS	Quartile	All	0.241	0.435	.016	16	view →
THCA	OS	Tertile	II,III,IV	0.928	0.983	.024	15	view →
OV	OS	Tertile	IV	0.739	0.339	.024	12	view →
READ	DFS	Tertile	IV	0.912	0.489	.035	12	view →
LIHC	DFS	Tertile	II,III,IV	0.100	0.463	.048	9	view →
DLBC	DFS	Tertile	All	0.510	0.834	.032	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

IGHD7-27–UCEC (OS)

Open the UCEC breakdown →