IGHD7-27

Across TCGA pan-cancer cohorts, IGHD7-27 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of IGHD7-27’s most consistent transcriptional readouts.

The strongest signal is observed in stomach adenocarcinoma (STAD), where IGHD7-27 RNA is repressed in tumor relative to normal tissue. In most cancer types IGHD7-27 is over-expressed in tumor, although a few such as STAD show the opposite, repressed pattern.

STAD are the cancer types where IGHD7-27 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHD7-27 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
STAD	Male	IV	−2.890	<.001	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 1 strongest of 1 lineages.

IGHD7-27–STAD

Open the STAD breakdown →