IGHD4-11

Across TCGA patient cohorts, IGHD4-11 RNA expression is significantly associated with the protein abundance of many other proteins, with 8,886 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IGHD4-11-associated proteins across cancer lineages are MZB1, SEPTIN6, and NCKAP1L. Each is linked with IGHD4-11 in more than 6 cancer types. Because this analysis shows association rather than direction, both IGHD4-11-to-partner and partner-to-IGHD4-11 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGHD4-11 versus MZB1 in BRCA, with a Pearson correlation of 0.38.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHD4-11→partner) and Y-score (partner→IGHD4-11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MZB1 →	+1.120	+0.786	<.001	<.001	3	7
CCRCC	SEPTIN6 →	+0.350	+0.815	<.001	<.001	3	6
LSCC	NCKAP1L →	+0.378	+1.666	<.001	<.001	3	5
LSCC	ACAP1 →	+0.648	+2.363	<.001	<.001	3	5
BRCA	WAS →	+0.443	+1.006	<.001	<.001	3	5
BRCA	TXNDC5 →	+0.698	+0.786	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,886 associations by consensus.

IGHD4-11 vs MZB1 — BRCA

Explore this scatter interactively →