IGHD4-11

Across TCGA pan-cancer cohorts, IGHD4-11 RNA is linked to patient survival in 9 of 34 cancer types, making it the most broadly survival-associated IGHD4-11 data layer.

The strongest signal is observed in lymphoid neoplasm diffuse large b-cell lymphoma (DLBC), where higher IGHD4-11 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated IGHD4-11 expression acts as an unfavorable survival marker, although some lineages such as LUAD and SKCM show a favorable association.

DLBC, READ, and LUAD are the cancer types where IGHD4-11 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
DLBC	OS	Tertile	III,IV	0.610	1.000	.004	69	view →
READ	DFS	Tertile	IV	0.255	0.628	.020	18	view →
LUAD	DFS	Tertile	II,III,IV	0.788	0.608	.042	12	view →
LAML	DFS	Median	All	0.280	0.485	.018	10	view →
THCA	OS	Tertile	III,IV	0.598	0.888	.038	9	view →
SKCM	OS	Tertile	III,IV	0.634	0.377	.031	6	view →
BRCA	DFS	Tertile	III,IV	0.792	0.439	.035	6	view →
HNSC	DFS	Tertile	All	0.432	0.676	.026	6	view →
KIRC	OS	Tertile	All	0.658	0.814	.048	3	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

IGHD4-11–DLBC (OS)

Open the DLBC breakdown →