IGHD4-11

Across TCGA pan-cancer cohorts, IGHD4-11 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of IGHD4-11’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where IGHD4-11 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IGHD4-11 is over-expressed in tumor, although a few such as COAD and READ show the opposite, repressed pattern.

LUAD, COAD, and READ are the cancer types where IGHD4-11 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHD4-11 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	All	+0.698	<.001	3	view →
COAD	All	All	−0.587	.013	3	view →
READ	All	III,IV	−2.245	.009	2	view →
KIRC	Male	All	+0.173	.042	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

IGHD4-11–LUAD

Open the LUAD breakdown →