Across TCGA patient cohorts, IGHD3-10 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGHD3-10-associated genes across cancer lineages are MIR4719, TRIM64, and RNU6ATAC21P. Each is linked with IGHD3-10 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGHD3-10-to-partner and partner-to-IGHD3-10 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHD3-10→partner) and Y-score (partner→IGHD3-10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR4719 →	+0.672	+8.066	<.001	.007	3	1
UCEC	TRIM64 →	+0.034	+8.066	<.001	.007	3	1
UCEC	RNU6ATAC21P →	+0.510	+8.066	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Exploration

IGHD3-10 survival (RNA) · tumor vs normal (RNA) · all IGHD3-10 data types