Across TCGA patient cohorts, IGHD1-14 RNA expression is significantly associated with the protein abundance of many other proteins, with 9,030 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IGHD1-14-associated proteins across cancer lineages are MZB1, ARHGAP25, and ARHGAP4. Each is linked with IGHD1-14 in more than 5 cancer types. Because this analysis shows association rather than direction, both IGHD1-14-to-partner and partner-to-IGHD1-14 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHD1-14→partner) and Y-score (partner→IGHD1-14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MZB1 →	+1.532	+0.506	<.001	<.001	3	6
BRCA	ARHGAP25 →	+0.681	+0.506	<.001	<.001	3	6
UCEC	ARHGAP4 →	+0.498	+1.271	<.001	.001	3	6
BRCA	RASAL3 →	+0.617	+0.620	<.001	.002	3	6
BRCA	ADA2 →	+0.596	+0.411	<.001	.007	3	6
LSCC	BTK →	+0.548	+2.316	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,030 associations by consensus.

Exploration

IGHD1-14 survival (RNA) · tumor vs normal (RNA) · all IGHD1-14 data types