Across TCGA pan-cancer cohorts, IGHD1-14 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of IGHD1-14’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGHD1-14 RNA is repressed in tumor relative to normal tissue. In most cancer types IGHD1-14 is over-expressed in tumor, although a few such as COAD and THCA show the opposite, repressed pattern.

COAD, LUAD, and THCA are the cancer types where IGHD1-14 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHD1-14 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−0.420	.037	1	view →
LUAD	Female	All	+0.290	.041	1	view →
THCA	All	All	−0.227	.027	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: IGHD1-14 RNA expression & survival · all IGHD1-14 data types