Across TCGA pan-cancer cohorts, IGHD1-14 RNA is linked to patient survival in 8 of 34 cancer types, making it the most broadly survival-associated IGHD1-14 data layer.
The strongest signal is observed in lung adenocarcinoma (LUAD), where higher IGHD1-14 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGHD1-14 expression acts as an unfavorable survival marker, although some lineages such as LUAD and BLCA show a favorable association.
LUAD, LAML, and KIRP are the cancer types where IGHD1-14 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.