IGHD1-1

Across TCGA patient cohorts, IGHD1-1 RNA expression is significantly associated with the protein abundance of many other proteins, with 8,716 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IGHD1-1-associated proteins across cancer lineages are DOCK2, WAS, and ARHGAP4. Each is linked with IGHD1-1 in more than 7 cancer types. Because this analysis shows association rather than direction, both IGHD1-1-to-partner and partner-to-IGHD1-1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGHD1-1 versus DOCK2 in LSCC, with a Pearson correlation of 0.66.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHD1-1→partner) and Y-score (partner→IGHD1-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DOCK2 →	+0.544	+1.974	<.001	<.001	3	8
UCEC	WAS →	+0.462	+1.097	<.001	.004	3	7
UCEC	ARHGAP4 →	+0.391	+1.375	<.001	.003	2	8
LSCC	ARHGAP45 →	+0.455	+1.790	<.001	<.001	3	7
LSCC	CD38 →	+0.937	+2.276	<.001	<.001	3	7
LSCC	IL16 →	+0.576	+1.877	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,716 associations by consensus.

IGHD1-1 vs DOCK2 — LSCC

Explore this scatter interactively →