IGHD1-1

Across TCGA pan-cancer cohorts, IGHD1-1 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated IGHD1-1 data layer.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher IGHD1-1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated IGHD1-1 expression acts as an unfavorable survival marker, although some lineages such as SKCM and HNSC show a favorable association.

SKCM, UVM, and TGCT are the cancer types where IGHD1-1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Tertile	All	0.516	0.314	<.001	114	view →
UVM	OS	Tertile	II,III,IV	0.218	0.718	.006	72	view →
TGCT	OS	Tertile	II,III,IV	0.501	0.996	<.001	72	view →
KIRP	DFS	Tertile	All	0.558	0.866	<.001	66	view →
MESO	OS	Tertile	IV	0.155	0.624	.004	18	view →
THCA	OS	Tertile	IV	0.813	1.000	.039	18	view →
LGG	DFS	Tertile	All	0.142	0.757	<.001	18	view →
READ	DFS	Tertile	All	0.549	0.852	.019	18	view →
LAML	DFS	Tertile	All	0.293	0.559	.007	16	view →
HNSC	DFS	Tertile	III,IV	0.835	0.641	.022	15	view →
KIRC	DFS	Tertile	III,IV	1.000	0.718	.006	12	view →
BLCA	DFS	Tertile	IV	0.227	0.476	.034	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

IGHD1-1–SKCM (OS)

Open the SKCM breakdown →