IGHD1-1

Across TCGA pan-cancer cohorts, IGHD1-1 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of IGHD1-1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGHD1-1 RNA is repressed in tumor relative to normal tissue. In most cancer types IGHD1-1 is over-expressed in tumor, although a few such as COAD and READ show the opposite, repressed pattern.

COAD, READ, and KIRP are the cancer types where IGHD1-1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHD1-1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	All	−0.888	.001	7	view →
READ	All	III,IV	−2.175	.009	2	view →
KIRP	All	All	−0.285	.020	1	view →
KIRC	Male	All	+0.181	.044	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

IGHD1-1–COAD

Open the COAD breakdown →