IGFBP1

Across TCGA patient cohorts, IGFBP1 mutation is significantly associated with the RNA expression of many other genes, with 1,206 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGFBP1-associated genes across cancer lineages are NF1P10, RNY4P27, and RNA5SP204. Each is linked with IGFBP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGFBP1-to-partner and partner-to-IGFBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NF1P10 grouped by IGFBP1-low versus IGFBP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGFBP1→partner) and Y-score (partner→IGFBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NF1P10 →	+0.125	+2.078	.003	.006	3	2
UCEC	RNY4P27 →	+0.131	+3.038	.002	.006	3	2
UCEC	RNA5SP204 →	+0.307	+2.111	.003	.003	3	2
UCEC	MIR520H →	+0.182	+3.167	<.001	.005	3	2
UCEC	RNA5SP164 →	+0.087	+3.973	<.001	.006	3	2
UCEC	RNA5SP416 →	+0.379	+2.108	.004	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,206 associations by consensus.

NF1P10 by IGFBP1 expression — UCEC

Explore this box plot interactively →