IGFBP1

Across TCGA pan-cancer cohorts, IGFBP1 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated IGFBP1 data layer compared with 2 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher IGFBP1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated IGFBP1 expression acts as an unfavorable survival marker, although some lineages such as SKCM and BRCA show a favorable association.

STAD, LUAD, and ESCA are the cancer types where IGFBP1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	DFS	Median	II,III,IV	0.290	0.497	<.001	109	view →
LUAD	DFS	Median	All	0.732	0.847	<.001	67	view →
ESCA	OS	Tertile	II,III,IV	0.515	0.823	<.001	59	view →
KIRC	DFS	Tertile	All	0.498	0.669	<.001	40	view →
MESO	OS	Median	III,IV	0.443	0.664	.005	34	view →
SKCM	OS	Median	All	0.419	0.270	.001	33	view →
BRCA	DFS	Median	II,III,IV	0.612	0.462	.004	20	view →
THCA	DFS	Tertile	All	0.941	0.848	.006	20	view →
KIRP	DFS	Tertile	III,IV	0.465	0.741	.023	16	view →
COAD	OS	Median	III,IV	0.247	0.720	.011	12	view →
SCLC	DFS	Tertile	IV	0.119	0.489	.029	12	view →
PRAD	DFS	Quartile	All	0.817	0.912	.002	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

IGFBP1–STAD (DFS)

Open the STAD breakdown →