Across TCGA cell cohorts, IGF2R mutation is significantly associated with the RNA expression of many other genes, with 916 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IGF2R-associated genes across cancer lineages are CUEDC2, FEM1A, and FAM98C. Each is linked with IGF2R in more than 2 cancer types. Because this analysis shows association rather than direction, both IGF2R-to-partner and partner-to-IGF2R results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGF2R→partner) and Y-score (partner→IGF2R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CUEDC2 →	+0.548	+2.179	<.001	.001	3	3
LARGE_INTESTINE	FEM1A →	+0.466	+3.404	.001	<.001	3	3
BLOOD_Leukemia	FAM98C →	+0.548	+2.837	.003	<.001	3	3
BLOOD_Leukemia	PHF5A →	+0.406	+2.145	.001	.006	3	2
LARGE_INTESTINE	STUB1 →	+0.350	+3.459	.002	.001	3	2
LARGE_INTESTINE	MTFMT →	+0.490	+3.459	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 916 associations by consensus.

Exploration

IGF2R survival (RNA) · tumor vs normal (RNA) · all IGF2R data types