IFT57

Across TCGA patient cohorts, IFT57 mutation is significantly associated with the RNA expression of many other genes, with 1,512 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IFT57-associated genes across cancer lineages are FDPS, TYMSOS, and ADAT1. Each is linked with IFT57 in more than 1 cancer types. Because this analysis shows association rather than direction, both IFT57-to-partner and partner-to-IFT57 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FDPS grouped by IFT57-low versus IFT57-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFT57→partner) and Y-score (partner→IFT57) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FDPS →	+0.710	+3.343	.001	.005	3	2
UCEC	TYMSOS →	+0.776	+3.354	<.001	.005	3	2
UCEC	ADAT1 →	+0.650	+3.338	<.001	.005	3	2
UCEC	IGHD2-2 →	+1.224	+2.012	.003	.005	3	2
UCEC	SC4MOP →	+0.051	+3.868	.001	<.001	3	2
UCEC	GOT2P1 →	+0.040	+2.835	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,512 associations by consensus.

FDPS by IFT57 expression — UCEC

Explore this box plot interactively →