IFT57

Across TCGA pan-cancer cohorts, IFT57 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of IFT57’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where IFT57 RNA is repressed in tumor relative to normal tissue. In most cancer types IFT57 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and LUSC are the cancer types where IFT57 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IFT57 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−2.177	<.001	10	view →
THCA	All	All	−0.405	<.001	10	view →
LUSC	All	III,IV	−2.086	<.001	9	view →
LUAD	Male	II,III,IV	−1.806	<.001	9	view →
HNSC	Male	III,IV	+0.891	<.001	8	view →
CHOL	All	All	+2.751	<.001	5	view →
KIRC	Male	II,III,IV	−0.335	.004	5	view →
LIHC	All	II,III,IV	+0.545	.019	3	view →
ESCA	All	All	+0.776	.001	2	view →
UCEC	All	All	−0.574	.023	2	view →
BLCA	All	IV	−0.614	.031	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

IFT57–KICH

Open the KICH breakdown →