IFT122

Across TCGA patient cohorts, IFT122 mutation is significantly associated with the RNA expression of many other genes, with 5,428 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IFT122-associated genes across cancer lineages are TRIM16L, NARS1, and RNU6-1178P. Each is linked with IFT122 in more than 2 cancer types. Because this analysis shows association rather than direction, both IFT122-to-partner and partner-to-IFT122 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRIM16L grouped by IFT122-low versus IFT122-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFT122→partner) and Y-score (partner→IFT122) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TRIM16L →	+0.643	+2.010	<.001	<.001	3	3
UCEC	NARS1 →	+0.556	+2.584	<.001	<.001	3	3
SKCM	RNU6-1178P →	+0.234	+2.347	<.001	.009	3	3
UCEC	NDUFA12 →	+0.300	+2.370	<.001	<.001	3	3
UCEC	LDHAP1 →	+0.087	+1.494	.003	.003	3	3
UCEC	ATP5F1A →	+0.360	+1.332	.003	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,428 associations by consensus.

TRIM16L by IFT122 expression — UCEC

Explore this box plot interactively →