IFT122

Across TCGA pan-cancer cohorts, IFT122 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of IFT122’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where IFT122 RNA is repressed in tumor relative to normal tissue. In most cancer types IFT122 is over-expressed in tumor, although a few such as KICH and LUAD show the opposite, repressed pattern.

KICH, HNSC, and LIHC are the cancer types where IFT122 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IFT122 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	All	−2.049	<.001	10	view →
HNSC	Male	III,IV	+0.921	<.001	8	view →
LIHC	Female	II,III,IV	+0.715	<.001	7	view →
BRCA	All	III,IV	+0.731	<.001	6	view →
CHOL	All	All	+1.911	<.001	5	view →
STAD	Male	II,III,IV	+0.717	.001	5	view →
COAD	All	All	+0.361	<.001	4	view →
LUAD	All	All	−0.259	.007	3	view →
THCA	Male	II,III,IV	−0.402	.025	2	view →
LUSC	All	All	+0.326	.013	2	view →
KIRC	Female	All	+0.406	.014	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

IFT122–KICH

Open the KICH breakdown →