IFNK

Across TCGA cell cohorts, IFNK RNA expression is significantly associated with the go_rna of many other GO terms, with 301 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible IFNK-associated GO terms across cancer lineages are Axon extension, Peripheral nervous system myelin maintenance, and Regulation of hair follicle development. Each is linked with IFNK in more than 2 cancer types. Because this analysis shows association rather than direction, both IFNK-to-partner and partner-to-IFNK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Axon extension grouped by IFNK-low versus IFNK-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IFNK→partner) and Y-score (partner→IFNK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Axon extension →	+0.066	+0.022	.001	.004	3	3
UPPER_AERODIGESTIVE_TRACT	Peripheral nervous system myelin maintenance →	+0.133	+0.059	<.001	.008	3	3
LUNG_NSCLC_LUAD	Regulation of hair follicle development →	+0.137	+0.012	.003	.008	3	3
LIVER	Negative regulation of bicellular tight junction assembly →	-0.108	-0.018	.004	.004	3	3
LIVER	Positive regulation of toll-like receptor signaling pathway →	+0.172	+0.018	<.001	.004	3	3
BLOOD_Lymphoma	Regulation of tumor necrosis factor-mediated signaling pathway →	+0.052	+0.021	.007	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 301 associations by consensus.

Axon extension by IFNK expression — BLOOD_Lymphoma

Explore this box plot interactively →