IFNK

Across TCGA pan-cancer cohorts, IFNK RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated IFNK data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IFNK RNA is associated with worse overall survival. In most high-consensus cancer types, elevated IFNK expression acts as an unfavorable survival marker, although some lineages such as PRAD and STAD show a favorable association.

HNSC, MESO, and THCA are the cancer types where IFNK RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.701	0.795	.002	94	view →
MESO	OS	Tertile	IV	0.151	0.677	.001	45	view →
THCA	OS	Tertile	III,IV	0.730	0.981	.004	42	view →
CESC	OS	Tertile	III,IV	0.298	0.817	.003	42	view →
BRCA	OS	Tertile	II,III,IV	0.515	0.585	.012	27	view →
KIRC	DFS	Median	All	0.571	0.666	.010	21	view →
PRAD	DFS	Quartile	All	0.988	0.918	.003	18	view →
KICH	DFS	Quartile	All	0.732	0.923	.030	16	view →
SKCM	DFS	Median	IV	0.258	0.664	.012	15	view →
STAD	DFS	Tertile	III,IV	0.717	0.512	.018	12	view →
LUSC	DFS	Quartile	II,III,IV	0.498	0.803	.005	7	view →
ESCA	DFS	Median	II,III,IV	0.454	0.880	.040	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

IFNK–HNSC (OS)

Open the HNSC breakdown →