IFNK

Across TCGA pan-cancer cohorts, IFNK RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of IFNK’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where IFNK RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IFNK is over-expressed in tumor, although a few such as BRCA and THCA show the opposite, repressed pattern.

KIRC, BRCA, and THCA are the cancer types where IFNK tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IFNK RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	II,III,IV	+0.026	.006	4	view →
BRCA	All	III,IV	−0.066	.015	2	view →
THCA	Female	II,III,IV	−0.076	.013	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

IFNK–KIRC

Open the KIRC breakdown →