IFNA4

Across TCGA patient cohorts, IFNA4 mutation is significantly associated with the RNA expression of many other genes, with 704 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IFNA4-associated genes across cancer lineages are OR2P1P, RNU6-433P, and SIGLEC27P. Each is linked with IFNA4 in more than 1 cancer types. Because this analysis shows association rather than direction, both IFNA4-to-partner and partner-to-IFNA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2P1P grouped by IFNA4-low versus IFNA4-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFNA4→partner) and Y-score (partner→IFNA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	OR2P1P →	+0.052	+5.655	<.001	.004	3	2
SKCM	RNU6-433P →	+0.258	+4.343	<.001	<.001	3	2
SKCM	SIGLEC27P →	+0.038	+4.408	<.001	.005	3	2
UCEC	ATAD3A →	+0.437	+3.483	.005	.002	3	2
UCEC	TXN2P1 →	+0.302	+1.939	<.001	.009	3	2
SKCM	C1GALT1P2 →	+0.087	+3.225	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 704 associations by consensus.

OR2P1P by IFNA4 expression — HNSC

Explore this box plot interactively →