Across TCGA pan-cancer cohorts, IFNA4 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of IFNA4’s most consistent transcriptional readouts.
The strongest signal is observed in breast invasive carcinoma (BRCA), where IFNA4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IFNA4 is over-expressed in tumor.
BRCA are the cancer types where IFNA4 tumor–normal differential expression is most reproducible.