IFIT3

Across TCGA patient cohorts, IFIT3 mutation is significantly associated with the RNA expression of many other genes, with 1,143 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IFIT3-associated genes across cancer lineages are FAM223B, SNRPGP17, and RNU2-47P. Each is linked with IFIT3 in more than 1 cancer types. Because this analysis shows association rather than direction, both IFIT3-to-partner and partner-to-IFIT3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM223B grouped by IFIT3-low versus IFIT3-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFIT3→partner) and Y-score (partner→IFIT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FAM223B →	+0.082	+5.505	<.001	.002	3	2
UCEC	SNRPGP17 →	+0.261	+2.241	.002	.002	3	2
UCEC	RNU2-47P →	+0.092	+4.253	<.001	.004	3	2
UCEC	RN7SL149P →	+0.133	+2.798	<.001	.001	3	2
UCEC	RNU6-358P →	+0.301	+2.548	.002	.007	3	2
BRCA	MIR4726 →	+0.427	+5.382	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,143 associations by consensus.

FAM223B by IFIT3 expression — BRCA

Explore this box plot interactively →