IFIT3

Across TCGA pan-cancer cohorts, IFIT3 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of IFIT3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where IFIT3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IFIT3 is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

HNSC, KIRC, and KICH are the cancer types where IFIT3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IFIT3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+3.683	<.001	11	view →
KIRC	Female	All	+0.850	<.001	11	view →
KICH	Female	All	−1.617	<.001	9	view →
LUSC	Female	All	−1.397	<.001	7	view →
BLCA	All	All	+1.190	.002	7	view →
THCA	Male	II,III,IV	+1.061	<.001	7	view →
LUAD	Male	All	−0.981	<.001	7	view →
UCEC	All	All	−1.009	.002	6	view →
STAD	All	II,III,IV	+1.112	.005	5	view →
BRCA	All	All	+0.613	<.001	4	view →
LIHC	All	All	+0.563	.031	3	view →
CHOL	Female	All	+2.929	.014	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

IFIT3–HNSC

Open the HNSC breakdown →