IFI44

Across TCGA patient cohorts, IFI44 mutation is significantly associated with the RNA expression of many other genes, with 2,793 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IFI44-associated genes across cancer lineages are ZNF280B, FARP1, and C19orf47. Each is linked with IFI44 in more than 1 cancer types. Because this analysis shows association rather than direction, both IFI44-to-partner and partner-to-IFI44 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF280B grouped by IFI44-low versus IFI44-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFI44→partner) and Y-score (partner→IFI44) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZNF280B →	+0.466	+2.081	.001	.001	3	2
UCEC	FARP1 →	+0.411	+1.747	.006	.004	3	2
UCEC	C19orf47 →	+0.356	+3.917	.002	<.001	3	2
UCEC	BRI3 →	+0.331	+3.470	.005	.002	3	2
UCEC	CDK5 →	+0.380	+2.763	.001	.002	3	2
UCEC	TMUB1 →	+0.326	+2.828	.008	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,793 associations by consensus.

ZNF280B by IFI44 expression — UCEC

Explore this box plot interactively →